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Single bacterial cell detection with nonlinear rotational frequency shifts of driven magnetic microspheres

Appl. Phys. Lett. 91, 224105 (2007); doi:10.1063/1.2817593

Published 29 November 2007

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Brandon H. McNaughton
Department of Physics, University of Michigan, Ann Arbor, Michigan 48109-1040, USA

Rodney R. Agayan
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA

Roy Clarke
Department of Physics, University of Michigan, Ann Arbor, Michigan 48109-1040, USA

Ron G. Smith and Raoul Kopelman
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
Shifts in the nonlinear rotational frequency of magnetic microspheres, driven by an external magnetic field, offer a dynamic approach for the detection of single bacterial cells. We demonstrate this capability by optically measuring such frequency shifts when an Escherichia coli attaches to the surface of a 2.0  µm magnetic microsphere, thereby affecting the drag of the system. From this change in drag, the nonlinear rotation rate was reduced, on average, by a factor of 3.8. Sequential bacterial cell attachments were also monitored. ©2007 American Institute of Physics
History: Received 27 July 2007; accepted 30 October 2007; published 29 November 2007
Permalink: http://link.aip.org/link/?APPLAB/91/224105/1
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KEYWORDS and PACS

Keywords
PACS
  • 75.50.Tt
    Fine-particle magnetic systems; nanocrystalline materials
  • YEAR: 2007

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ISSN:
0003-6951 (print)   1077-3118 (online)
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