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Microbubble-enhanced ultrasound-modulated fluorescence in a turbid medium

Appl. Phys. Lett. 95, 181113 (2009); doi:10.1063/1.3262959

Published 6 November 2009

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Baohong Yuan,1 Yuan Liu,1 Patrick M. Mehl,2 and Joseph Vignola3
1Department of Biomedical Engineering, Catholic University of America, Washington DC 20064, USA
2Vitreous State Laboratory, Catholic University of America, Washington DC 20064, USA
3Department of Mechanical Engineering, Catholic University of America, Washington DC 20064, USA
The feasibility of using ultrasound to modulate fluorescence in a turbid medium is still in debate due to the difficulty of detecting the modulated signal. We have demonstrated a system that could detect the weak signals of ultrasound-modulated fluorescence (UMF) by using a broadband lock-in amplifier and microbubbles as enhancement agents. By detecting the microbubble-enhanced UMF signal, a sub-millimeter fluorescent tube submerged in a turbid medium with a depth of 2 cm has been clearly observed with an ultrasonic spatial resolution. The modulation efficiency was significantly improved by using microbubbles, and was found to linearly increase with the drive voltage applied to the ultrasound transducer and the fluorophore concentration within the range adopted in this study. Possible modulation mechanisms are discussed. ©2009 American Institute of Physics
History: Received 25 August 2009; accepted 17 October 2009; published 6 November 2009
Permalink: http://link.aip.org/link/?APPLAB/95/181113/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.63.dh
    Ultrasonographic medical imaging
  • 87.64.kv
    Fluorescence spectroscopy in biophysics and medical physics
  • YEAR: 2010

PUBLICATION DATA

ISSN:
0003-6951 (print)   1077-3118 (online)
Publisher:
AIP is a member of CrossRef AIP

REFERENCES (11)
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