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Calcium ions (Ca2+) are an important second messenger in eucaryotic cells. They are involved in numerous physiological processes which are triggered by calcium signals in the form of local release eve...
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What can we learn from the irregularity of Ca2+ oscillations?
In most cells, Ca2+ increases in response to external stimulation are organized in the form of oscillations and waves that sometimes propagate from one cell to another. Numerous experimental and theor...

From puffs to global Ca2+ signals: How molecular properties shape global signals

Chaos 19, 037111 (2009); doi:10.1063/1.3184537

Published 18 September 2009

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Alexander Skupin1,2 and Martin Falcke2
1Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14776 Potsdam-Golm, Germany
2Max-Delbrück-Centre, Robert-Rössle Str. 10, 13125 Berlin, Germany
The universality of Ca2+ as second messenger in living cells is achieved by a rich spectrum of spatiotemporal cellular concentration dynamics. Ca2+ release from internal storage compartments plays a key role in shaping cytosolic Ca2+ signals. Deciphering this signaling mechanism is essential for a deeper understanding of its physiological function and general concepts of cell signaling. Here, we review recent experimental findings demonstrating the stochasticity of Ca2+ oscillations and its relevance for modeling Ca2+ dynamics. The stochasticity arises by the hierarchical signal structure that carries molecular fluctuations of single channels onto the level of the cell leading to a stochastic medium as theoretically predicted. The result contradicts the current opinion of Ca2+ being a cellular oscillator. We demonstrate that cells use array enhanced coherence resonance to form rather regular spiking signals and that the “oscillations” carry information despite the involved stochasticity. The knowledge on the underlying mechanism also allows for determination of intrinsic properties from global observations. In the second part of the paper, we briefly survey different modeling approaches with regard to the experimental results. We focus on the dependence of the standard deviation on the mean period of the oscillations. It shows that limit cycle oscillations cannot describe the experimental data and that generic models have to include the spatial aspects of Ca2+ signaling. ©2009 American Institute of Physics
History: Received 18 February 2009; accepted 30 June 2009; published 18 September 2009
Permalink: http://link.aip.org/link/?CHAOEH/19/037111/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.16.Uv
    Intracellular active transport processes
  • 87.16.dp
    Transport in biomembranes, bilayers and vesicles
  • 87.16.Vy
    Ion channels
  • 87.16.Xa
    Intracellular signaling and signal transduction
  • YEAR: 2009

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PUBLICATION DATA

ISSN:
1054-1500 (print)   1089-7682 (online)
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