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This study addresses the question of selection and amplitude scaling of accelerograms for predicting the nonlinear seismic response of structures. Despite the current practices of record selection according to a specific magnitude-distance scenario and scaling to a common level, neither aspect of this process has received significant research attention to ascertain the benefits or effects of these practices on the conclusions. This paper hypothesizes that neither these usual principal seismological characteristics nor scaling of records matters to the nonlinear response of structures. It then investigates under what conditions this hypothesis may not be sustainable. Two classes of records sets are compared in several case studies: one class is carefully chosen to represent a specific magnitude and distance scenario, the other is chosen randomly from a large catalog. Results of time-history analyses are formally compared by a simple statistical hypothesis test to assess the difference, if any, between nonlinear demands of the two classes of records. The effect of the degree of scaling (by first-mode spectral acceleration level) is investigated in the same way. Results here show (1) little evidence to support the need for a careful site-specific process of record selection by magnitude and distance, and (2) that concern over scenario-to-scenario record scaling, at least within the limits tested, may not be justified. ©2005 Earthquake Engineering Research Institute