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Effect of electrodiffusion current flow on electrostatic screening in aqueous pores

J. Appl. Phys. 103, 084701 (2008); doi:10.1063/1.2906327

Published 18 April 2008

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Yang Liu,1 Jon Sauer,2 and Robert W. Dutton1
1Center for Integrated Systems, Stanford University, Stanford, California 94305-4075, USA
2Eagle Research & Development, LLC, Boulder, Colorado 80301, USA
A numerical study within the framework of the Poisson–Nernst–Planck equations is conducted to investigate electrostatic screening of charged biomolecules within synthetic pores having diameters of at least 10  Debye lengths. We show that with external biases, the biomolecule charge is only partially screened due to the presence of electro-diffusion current flow. This is considerably different from the equilibrium Debye–Huckel screening behavior and will result in long-range electrostatic interactions. The potential application to direct biomolecule charge sensing is also discussed. ©2008 American Institute of Physics
History: Received 20 December 2007; accepted 12 February 2008; published 18 April 2008
Permalink: http://link.aip.org/link/?JAPIAU/103/084701/1
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KEYWORDS and PACS

Keywords
PACS
  • 66.10.C-
    Diffusion and thermal diffusion in liquids
  • YEAR: 2008

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ISSN:
0021-8979 (print)   1089-7550 (online)
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REFERENCES (21)
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  1. J. J. Kasianowicz, E. Brandin, D. Branton, and D. W. Deamer, Proc. Natl. Acad. Sci. U.S.A. 93, 13770 (1996).
  2. S. Howorka, S. Cheley, and H. Bayley, Nat. Biotechnol. 19, 636 (2001).
  3. A. Meller, L. Nivon, and D. Branton, Phys. Rev. Lett. 86, 3435 (2001).
  4. S. Matysiak, A. Montesi, M. Pasquali, A. B. Kolomeisky, and C. Clementi, Phys. Rev. Lett. 96, 118103 (2006).
  5. Y. Rabin and M. Tanaka, Phys. Rev. Lett. 94, 148103 (2005).
  6. Z. Siwy and A. Fulinski, Phys. Rev. Lett. 89, 198103 (2002);
    7. 91, 179802 (2003);
    Z. Siwy, I. D. Kosinska, A. Fulinski, and C. R. Martin, ibid. 94, 048102 (2005);
    C. Rischel and H. Flyvbjerg, ibid. 91, 179801 (2003).
  7. J. Sauer, personal communications (March 16, 2007);
    8. Also, J. Sauer and B. V. Zeghbroeck, US Patent No. 6,413,792 (July 2, 2002).
  8. P. Bergveld, Sens. Actuators B 88, 1 (2003);
    9. Biosens. Bioelectron. 6, 55 (1991).
  9. M. J. Schoning and A. Poghossian, Analyst (Cambridge, U.K.) 127, 1137 (2002).
  10. T. F. Weiss, Cellular Biophysics (MIT, Cambridge, MA, 1996), Vol. 1.
  11. K. A. Sharp and B. Honig, J. Phys. Chem. 94, 7684 (1990).
  12. R. S. Eisenberg, J. Membr. Biol. 150, 1 (1996).
  13. M. G. Kurnikova, R. D. Coalson, P. Graf, and A. Nitzan, Biophys. J. 76, 642 (1999).
  14. B. Corry, S. Kuyucak, and S.-H. Chung, Biophys. J. 78, 2364 (2000).
  15. See: http://www-tcad.stanford.edu/~prophet
  16. T. A. Van Der Stratten, J. M. Tang, U. Ravaioli, R. S. Eisenberg, and N. R. Aluru, J. Comput. Electron. 2, 29 (2003).
  17. A. Talasaz, M. Nemat-Gorgani, Y. Liu, P. Stahl, R. Dutton, M. Ronaghi, and R. Davis, Proc. Natl. Acad. Sci. U.S.A. 103, 14773 (2006).
  18. A. Offenhausser and W. Knoll, Trends Biotechnol. 19, 62 (2001).
  19. J. L. Freeman, G. H. Perry, L. Feuk, R. Redon, S. A. McCarroll, D. M. Altshuler, H. Aburatani, K. W. Jones, C. Tyler-Smith, M. E. Hurles, N. P. Carter, S. W. Scherer, and C. Lee, Genome Res. 16, 949 (2006).
  20. J. Li, D. Stein, C. McMullan, D. Branton, M. Aziz, and J. Golovchenko, Nature (London) 412, 166 (2001).
  21. A. J. Storm, J. Chen, X. Ling, H. Zandbergen, and C. Dekker, Nat. Mater. 2, 537 (2003).

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