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Effects of charge screening and surface properties on signal transduction in field effect nanowire biosensors

J. Appl. Phys. 106, 014701 (2009); doi:10.1063/1.3156657

Published 6 July 2009

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Yang Liu and Robert W. Dutton
Center for Integrated Systems, Stanford University, Stanford, California 94305-4075, USA
A self-consistent numerical model for silicon-based field effect nanowire biosensors is developed to study the impact of various surface-related physical and chemical processes, including transport of semiconductor carriers and electrolyte mobile ions, protonation and deprotonation of surface charge groups, and charges, and orientations and surface binding dynamics of immobilized biomolecules. It is shown that the sensing signal levels are affected by the gate biasing points, nonlinear screening from both electrolytes and surface charge groups, as well as the biomolecule charges and orientations. The critical role of the nanowire surface heterogeneity in determining the sensing input dynamic range is indicated based on correlations with experimental data. ©2009 American Institute of Physics
History: Received 5 February 2009; accepted 23 May 2009; published 6 July 2009
Permalink: http://link.aip.org/link/?JAPIAU/106/014701/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.80.-y
    Biophysical techniques (research methods)
  • 87.15.rs
    Dissociation in biochemical reactions
  • 87.15.hg
    Dynamics of intermolecular interactions in biomolecules
  • 85.30.Tv
    Semiconductor field effect devices
  • YEAR: 2009

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PUBLICATION DATA

ISSN:
0021-8979 (print)   1089-7550 (online)
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REFERENCES (30)
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  1. P. Bergveld, Sens. Actuators B 88, 1 (2003).
  2. E. Souteyrand et al., J. Phys. Chem. B 101, 2980 (1997).
  3. J. Hahm and C. M. Lieber, Nano Lett. 4, 51 (2004).
  4. Z. Li et al., Nano Lett. 4, 245 (2004).
  5. M. M.-C. Cheng et al., Curr. Opin. Chem. Biol. 10, 11 (2006).
  6. Y. L. Bunimovich et al., J. Am. Chem. Soc. 128, 16323 (2006).
  7. Z. Gao et al., Anal. Chem. 79, 3291 (2007).
  8. Y. Cui, Q. Wei, H. Park, and C. M. Lieber, Science 293, 1289 (2001).
  9. G. Zheng, F. Patolsky, Y. Cui, W. U. Wang, and C. M. Lieber, Nat. Biotechnol. 23, 1294 (2005).
  10. E. Stern et al., Nature (London) 445, 519 (2007).
  11. C. Heitzinger and G. Klimeck, J. Comput. Electron. 6, 387 (2007).
  12. P. R. Nair and M. A. Alam, IEEE Trans. Electron Devices 54, 3400 (2007).
  13. P. R. Nair and M. A. Alam, Nano Lett. 8, 1281 (2008).
  14. Y. Liu, J. Sauer, and R. W. Dutton, J. Appl. Phys. 103, 084701 (2008).
  15. Y. Liu, K. Lilja, C. Heitzinger, and R. W. Dutton, Tech. Dig. - Int. Electron Devices Meet. 2008, 491.
  16. D. Landheer, G. Aers, W. R. McKinnon, M. J. Deen, and J. C. Ranuarez, J. Appl. Phys. 98, 044701 (2005).
  17. D. L. Harame, L. J. Bousse, J. D. Shott, and J. D. Meindl, IEEE Trans. Electron Devices ED-34, 1700 (1987).
  18. A. J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications, 2th ed. (Wiley, New York, 2001).
  19. Y. Liu and R. W. Dutton, Transducers'09, Denver, CO, 2009, p. 1678-1681.
  20. H. Ohshima, K. Makino, and T. Kondo, J. Colloid Interface Sci. 116, 196 (1987).
  21. H. Ohshima and T. Kondo, J. Colloid Interface Sci. 123, 136 (1988).
  22. Y. Taur and T. H. Ning, Fundamental of Modern VLSI Devices (Cambridge University Press, Cambridge, 1998).
  23. L. Bousse, J. Chem. Phys. 76, 5128 (1982).
  24. E. D. Minot et al., Appl. Phys. Lett. 91, 093507 (2007).
  25. D. Deamer and A. Volkov, in Permeability and Stability of Lipid Bilayers, edited by E. A. Disalvo and S. A. Simon (CRC, Boca Raton, FL, 1995), Chap. 8, p. 161.
  26. R. Sips, J. Chem. Phys. 16, 490 (1948).
  27. I. Quinones and G. Guiochon, J. Colloid Interface Sci. 183, 57 (1996).
  28. A. Talasaz et al., Proc. Natl. Acad. Sci. U.S.A. 103, 14773 (2006).
  29. F. Yu, D. Yao, and W. Knoll, Nucleic Acids Res. 32, 75 (2004).
  30. R. Beckman, E. Johnston-Halperin, Y. Luo, J. E. Green, and J. R. Heath, Science 310, 465 (2005).

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