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Effects of charge screening and surface properties on signal transduction in field effect nanowire biosensors

J. Appl. Phys. 106, 014701 (2009); doi:10.1063/1.3156657

Published 6 July 2009

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Yang Liu and Robert W. Dutton
Center for Integrated Systems, Stanford University, Stanford, California 94305-4075, USA
A self-consistent numerical model for silicon-based field effect nanowire biosensors is developed to study the impact of various surface-related physical and chemical processes, including transport of semiconductor carriers and electrolyte mobile ions, protonation and deprotonation of surface charge groups, and charges, and orientations and surface binding dynamics of immobilized biomolecules. It is shown that the sensing signal levels are affected by the gate biasing points, nonlinear screening from both electrolytes and surface charge groups, as well as the biomolecule charges and orientations. The critical role of the nanowire surface heterogeneity in determining the sensing input dynamic range is indicated based on correlations with experimental data. ©2009 American Institute of Physics
History: Received 5 February 2009; accepted 23 May 2009; published 6 July 2009
Permalink: http://link.aip.org/link/?JAPIAU/106/014701/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.80.-y
    Biophysical techniques (research methods)
  • 87.15.rs
    Dissociation in biochemical reactions
  • 87.15.hg
    Dynamics of intermolecular interactions in biomolecules
  • 85.30.Tv
    Semiconductor field effect devices
  • YEAR: 2009

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ISSN:
0021-8979 (print)   1089-7550 (online)
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