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Erratum: “Local and global properties of mixtures in one-dimensional systems. I. Mixtures of two simple components” [J. Chem. Phys. 128, 084510 (2008)]

Dendrimers as synthetic gene vectors: Cell membrane attachment

J. Chem. Phys. 130, 155101 (2009); doi:10.1063/1.3109902

Published 16 April 2009

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N. K. Voulgarakis, K. Ø. Rasmussen, and P. M. Welch
Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain to critical issues arising in emerging gene delivery therapeutic applications, where a molecular carrier is required to deliver DNA segments to the interior of living cells. ©2009 American Institute of Physics
History: Received 8 October 2008; accepted 10 March 2009; published 16 April 2009
Permalink: http://link.aip.org/link/?JCPSA6/130/155101/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.14.gk
    DNA
  • 87.10.Tf
    Molecular dynamics simulation (biological/medical physics)
  • 87.16.D-
    Biomembranes, bilayers, and vesicles
  • YEAR: 2009

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PUBLICATION DATA

ISSN:
0021-9606 (print)   1089-7690 (online)
Publisher:
AIP is a member of CrossRef AIP

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