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The tissue diagnostic instrument

Rev. Sci. Instrum. 80, 054303 (2009); doi:10.1063/1.3127602

Published 27 May 2009

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Paul Hansma,1 Hongmei Yu,2 David Schultz,3 Azucena Rodriguez,3 Eugene A. Yurtsev,1 Jessica Orr,3 Simon Tang,3 Jon Miller,4 Joseph Wallace,5 Frank Zok,6 Cheng Li,7 Richard Souza,8 Alexander Proctor,9 Davis Brimer,9 Xavier Nogues-Solan,10 Leonardo Mellbovsky,10 M. Jesus Peña,10 Oriol Diez-Ferrer,10 Phillip Mathews,1 Connor Randall,1 Alfred Kuo,3 Carol Chen,3 Mathilde Peters,4 David Kohn,5 Jenni Buckley,3 Xiaojuan Li,8 Lisa Pruitt,7 Adolfo Diez-Perez,10 Tamara Alliston,3 Valerie Weaver,2 and Jeffrey Lotz3
1Department of Physics, University of California, Santa Barbara, California 93106, USA
2Department of Surgery, Department of Anatomy, Department of Bioengineering and Therapeutics, and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, California 94143, USA
3Department of Orthopaedic Surgery, University of California, San Francisco, California 94143, USA
4Department of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
5Department of Biologic and Materials Sciences and Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
6Department of Materials, University of California, Santa Barbara, California 93106, USA
7UC Berkeley and UCSF Joint Graduate Group in Bioengineering, Berkeley, California 94720, USA
8Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, USA
9Active Life Technologies, 629 State St., Suite 213, Santa Barbara, California 93101, USA
10Hospital del Mar, Department of Internal Medicine, Autonomous University of Barcelona, P. Maritim 25-29, 08003 Barcelona, Spain
Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection. ©2009 American Institute of Physics
History: Received 11 December 2008; accepted 13 April 2009; published 27 May 2009
Permalink: http://link.aip.org/link/?RSINAK/80/054303/1
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EPAPS

KEYWORDS and PACS

Keywords
PACS
  • 87.85.Ox
    Biomedical instrumentation and transducers
  • 87.19.xj
    Cancer
  • 87.19.R-
    Mechanical and electrical properties of tissues and organs (higher organisms)
  • YEAR: 2009

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PUBLICATION DATA

ISSN:
0034-6748 (print)   1089-7623 (online)
Publisher:
AIP is a member of CrossRef AIP

REFERENCES (27)
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