Review of Scientific Instruments
Feedback | Help | Exit
Review of Scientific Instruments
Search:
   
 
 
 
Previous Article
Dielectric barrier discharge source for supersonic beams
We present a new excitation source for pulsed supersonic beams. The excitation is based on dielectric barrier discharge in the beam. It produces cold beams of metastable atoms, dissociated neutral ato...
Next Article
Experimental method for in situ determination of material textures at simultaneous high pressure and high temperature by means of radial diffraction in the diamond anvil cell
We introduce the design and capabilities of a resistive heated diamond anvil cell that can be used for side diffraction at simultaneous high pressure and high temperature. The device can be used to st...

A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance -based molds

Rev. Sci. Instrum. 80, 104301 (2009); doi:10.1063/1.3242697

Published 12 October 2009

You are logged in to this journal.

Vijay Shah,1,2 Thomas Pohida,3 Baris Turkbey,2 Haresh Mani,4 Maria Merino,4 Peter A. Pinto,5 Peter Choyke,2 and Marcelino Bernardo1,2
1Imaging Physics, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 20892, USA
2Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892, USA
3Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA
4Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
5Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images in order to facilitate the process of correlating the images with histopathology is presented. The method is applied to radical prostatectomy specimens where the customized mold is designed using magnetic resonance (MR) images of each patient obtained prior to surgery. In this case, the mold holds the prostate in place while a knife with a single blade or multiple blades is inserted in slots which are positioned to obtain tissue blocks corresponding to the slices in the MR images. The resulting histological specimens demonstrate good anatomical correlation with the MR images. ©2009 American Institute of Physics
History: Received 8 April 2009; accepted 14 September 2009; published 12 October 2009
Permalink: http://link.aip.org/link/?RSINAK/80/104301/1
FULL TEXT OPTIONS   (FREE)
Download PDF (445 kB) View Cart

KEYWORDS and PACS

Keywords
PACS
  • 87.61.-c
    Medical magnetic resonance imaging
  • YEAR: 2009

RELATED DATABASES

Web of Science

View this record in Web of Science

PUBLICATION DATA

ISSN:
0034-6748 (print)   1089-7623 (online)
Publisher:
AIP is a member of CrossRef AIP

REFERENCES (22)
View in Separate Window/Tab
  1. Y. J. Choi, J. K. Kim, N. Kim, K. W. Kim, E. K. Choi, and K. S. Cho, Radiographics 27, 63 (2007). [MEDLINE]
  2. I. Ocak, M. Bernardo, G. Metzger, T. Barrett, P. Pinto, P. S. Albert, and P. L. Choyke, AJR, Am. J. Roentgenol. 189, W192 (2007).
  3. P. A. Rogerson, G. Sinha, and D. Han, Am. J. Prev. Med. 30, S50 (2006). [MEDLINE]
  4. A. Graser, A. Heuck, B. Sommer, J. Massmann, J. Scheidler, M. Reiser, and U. Mueller-Lisse, AJR, Am. J. Roentgenol. 188, 84 (2007). [MEDLINE]
  5. S. G. Jhavar, C. Fisher, A. Jackson, S. A. Reinsberg, N. Dennis, A. Falconer, D. Dearnaley, S. E. Edwards, S. M. Edwards, M. O. Leach, C. Cummings, T. Christmas, A. Thompson, C. Woodhouse, S. Sandhu, C. S. Cooper, and R. A. Eeles, J. Clin. Pathol. 58, 504 (2005). [MEDLINE]
  6. F. Kiessling, M. Le-Huu, T. Kunert, M. Thorn, S. Vosseler, K. Schmidt, J. Hoffend, H. P. Meinzer, N. E. Fusenig, and W. Semmler, Eur. Radiol. 15, 1079 (2005). [MEDLINE]
  7. P. Kozlowski, S. D. Chang, E. C. Jones, K. W. Berean, H. Chen, and S. L. Goldenberg, J. Magn. Reson Imaging 24, 108 (2006). [MEDLINE]
  8. A. Madabhushi, M. D. Feldman, D. N. Metaxas, J. Tomaszeweski, and D. Chute, IEEE Trans. Med. Imaging 24, 1611 (2005). [MEDLINE]
  9. N. Van As, E. Charles-Edwards, A. Jackson, S. Jhavar, S. Reinsberg, N. Desouza, D. Dearnaley, M. Bailey, A. Thompson, T. Christmas, C. Fisher, C. Corbishley, and S. Sohaib, Br. J. Radiol. 81, 456 (2008). [MEDLINE]
  10. J. J. Futterer, S. W. Heijmink, T. W. Scheenen, J. Veltman, H. J. Huisman, P. Vos, C. A. Hulsbergen-Van de Kaa, J. A. Witjes, P. F. Krabbe, A. Heerschap, and J. O. Barentsz, Radiology 241, 449 (2006). [Inspec] [MEDLINE]
  11. M. A. Haider, T. H. van der Kwast, J. Tanguay, A. J. Evans, A. T. Hashmi, G. Lockwood, and J. Trachtenberg, AJR, Am. J. Roentgenol. 189, 323 (2007). [MEDLINE]
  12. H. Miao, H. Fukatsu, and T. Ishigaki, Eur. J. Radiol. 61, 297 (2007). [MEDLINE]
  13. S. M. Noworolski, R. G. Henry, D. B. Vigneron, and J. Kurhanewicz, Magn. Reson. Med. 53, 249 (2005). [Inspec] [MEDLINE]
  14. S. W. Heijmink, T. W. Scheenen, E. N. van Lin, A. G. Visser, L. A. Kiemeney, J. A. Witjes, and J. O. Barentsz, Int. J. Radiat. Oncol., Biol., Phys. 73, 1446 (2009). [MEDLINE]
  15. S. Ashley, Mech. Eng. 117, 62 (1995).
  16. I. Gibson, Advanced Manufacturing Technology for Medical Applications-Reverse Engineering, Software Conversion and Rapid Prototyping (Wiley, New York, 2006).
  17. T. V. Martin Masters and F. McBagonluri, in Rapid Manufacturing Technologies: The Next Industrial Revolution, edited by N. Hopkinson, R. Haque, and P. Dickens (Wiley, New York, 2006), pp. 195–209.
  18. J. C. Nickel, Urol. Clin. North Am. 35, 109 (2008). [MEDLINE]
  19. C. R. Chapple, R. Crowe, S. A. Gilpin, J. Gosling, and G. Burnstock, J. Urol. 146, 1637 (1991).
  20. M. Orth, Pharm. Unserer Zeit 37, 315 (2008). [MEDLINE]
  21. S. Jonmarker, A. Valdman, A. Lindberg, M. Hellstrom, and L. Egevad, Virchows Arch. 449, 297 (2006). [MEDLINE]
  22. A. R. Schned, K. J. Wheeler, C. A. Hodorowski, J. A. Heaney, M. S. Ernstoff, R. J. Amdur, and R. D. Harris, Am. J. Surg. Pathol. 20, 1501 (1996). [MEDLINE]






Copyright © American Institute of Physics