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The dramatic exponential speedups of quantum algorithms over their best existing classical counterparts were ushered in by the technique of Fourier sampling, introduced by Bernstein and Vazirani and developed by Simon and Shor into an approach to the hidden subgroup problem. This approach has proved successful for abelian groups, leading to efficient algorithms for factoring, extracting discrete logarithms, and other number-theoretic problems. We show, however, that this method cannot resolve the hidden subgroup problem in the symmetric groups, even in the weakest, information-theoretic sense. In particular, we show that the Graph Isomorphism problem cannot be solved by this approach. Our work implies that any quantum approach based upon the measurement of coset states must depart from the original framework by using entangled measurements on multiple coset states.