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Structure of single-wall peptide nanotubes: in situ flow aligning X-ray diffraction

Source: Chem. Commun. 46, 6270 (2010); doi:10.1039/c0cc00212g

Issue Date: 30 August 2010

PUBLICATION DATA
ISSN:
1553-9644 (online)
Publisher:
AIP is a member of CrossRef RSC
Valeria Castelletto
Dept of Chemistry, University of Reading, Whiteknights Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk

David R. Nutt


Ian W. Hamley


Seyda Bucak


Çelen Cenker


Ulf Olsson

The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A6K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall. ©2010
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