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Charge pumping technique to analyze the effect of intrinsically retained charges and extrinsically trapped charges in biomolecules by use of a nanogap embedded biotransistor

Source: Appl. Phys. Lett. 96, 053702 (2010); doi:10.1063/1.3300838

Published 3 February 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.85.-d
    Biomedical engineering
  • 87.80.-y
    Biophysical techniques (research methods)
  • YEAR: 2010
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PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef AIP
Sungho Kim,1 Jae-Hyuk Ahn,1 Tae Jung Park,2 Sang Yup Lee,2,3 and Yang-Kyu Choi1
1School of Electrical Engineering and Computer Science, Division of Electrical Engineering, KAIST, Daejeon 305-701, Republic of Korea
2BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, KAIST, Daejeon 305-701, Republic of Korea
3Department of Bio and Brain Engineering, Department of Biological Sciences, and Bioinformatics Research Center, KAIST, Daejeon 305-701, Republic of Korea
Charge pumping technique is investigated for label-free electrical biosensing using a nanogap-embedded biotransistor. Biomolecules immobilized in a nanogap provide additional trap states and charges in the gate dielectric. These two effects give rise to a change of the charge pumping current, which are analyzed by the aid of numerical simulations. To utilize the trap density of gate dielectric as a sensing parameter, proper amplitude of pulse should be applied for charge pumping to exclude the effect of intrinsically retained charges in biomolecules, thereby this proposed technique is available for detection of biomolecules regardless of retained charges. ©2010 American Institute of Physics
History: Received 14 December 2009; accepted 7 January 2010; published 3 February 2010
Permalink: http://link.aip.org/link/?APPLAB/96/053702/1

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