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Enhanced photoacoustic stability of gold nanorods by silica matrix confinement

Source: J. Biomed. Opt. 15, 016010 (2010); doi:10.1117/1.3292574

Published 1 February 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.63.L-
    Visual medical imaging
  • 43.80.Qf
    Medical diagnosis with acoustics
  • 87.63.D-
    Ultrasonography in medicine
  • 43.80.Vj
    Acoustical medical instrumentation and measurement techniques
  • 43.58.-e
    Acoustical measurements and instrumentation
  • 87.63.dh
    Ultrasonographic medical imaging
  • 87.85.Rs
    Nanotechnologies - applications in biomedical engineering
  • 43.35.Ud
    Thermoacoustics, high temperature acoustics, photoacoustic effect
  • 87.85.J-
    Biomaterials (biomedical engineering)
  • YEAR: 2010
PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef SPIE
Leng-Chun Chen
National Health Research Institutes, Division of Medical Engineering Research, 35 Keyan Road, Zhunan, Miaoli Country 350, Taiwan

Chen-Wei Wei
National Taiwan University, Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei, 106 Taiwan

Jeffrey S. Souris
The University of Chicago, Department of Radiology, Chicago, Illinois 60637

Shih-Hsun Cheng
National Tsing Hua University, Institute of NanoEngineering and MicroSystems, Hsinchu, 300 Taiwan

Chin-Tu Chen
The University of Chicago, Department of Radiology, Chicago, Illinois 60637

Chung-Shi Yang
National Health Research Institutes, Center for Nanomedicine Research, Zhunan, 350 Taiwan

Pai-Chi Li
National Taiwan University, Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei, 106 Taiwan

Leu-Wei Lo
National Health Research Institutes, Division of Medical Engineering Research, 35 Keyan Road, Zhunan, Miaoli Country 350, Taiwan
Photoacoustic tomography (PAT) has garnered much attention for its high contrast and excellent spatial resolution of perfused tissues. Gold nanorods (GNRs) have been employed to further enhance the imaging contrast of PAT. However, the photon fluences typically needed for PA wave induction often also result in GNR shape changes that significantly reduce the efficiency of acoustic wave generation. In this work, we propose, synthesize, and evaluate amorphous silica-coated gold nanorods (GNR-Si) in an effort to improve contrast agent stability and ameliorate efficiency loss during photoacoustic (PA) wave induction. TEM and optical absorption spectra measurements of GNR and GNR-Si show that encasing GNRs within amorphous silica provides substantial protection of nanorod conformation from thermal deformation. PA signals generated by GNR-Si demonstrate considerably greater resistance to degradation of signal intensity with repetitive pulsing than do uncoated GNRs, thereby enabling much longer, high-contrast imaging sessions than previously possible. The prolongation of high-contrast imaging, and biocompatibility and easy surface functionalization for targeting ligands afforded by amorphous silica, suggest GNR-Si to be potentially significant for the clinical translation of PAT. ©2010 Society of Photo-Optical Instrumentation Engineers
History: Received 2 September 2009; revised 23 November 2009; accepted 24 November 2009; published 1 February 2010
Permalink: http://dx.doi.org/10.1117/1.3292574

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