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Enhancement of biosensing performance in a droplet-based bioreactor by in situ microstreaming

Source: Biomicrofluidics 4, 011102 (2010); doi:10.1063/1.3310930

Published 8 February 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.80.Ek
    Mechanical and micromechanical techniques (biophysical research methods)
  • 43.38.Rh
    Surface acoustic wave transducers
  • 43.25.Nm
    Acoustic streaming
  • 47.85.Np
    Fluidics (applied)
  • 82.80.-d
    Chemical analysis and related physical methods of analysis
  • 85.85.+j
    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
  • YEAR: 2010
RELATED DATABASES
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PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef AIP
Olivier Ducloux,1 Elisabeth Galopin,1 Farzam Zoueshtiagh,1,2 Alain Merlen,1,2 and Vincent Thomy1
1IEMN-Institut d'Electronique, Microélectronique et Nanotechnologie, 59650 Villeneuve d'Ascq, France
2LEMAC-Laboratoire Européen Associé en Magnéto-Acoustique non linéaire, 59650 Villeneuve d'Ascq, France
A droplet-based micro-total-analysis system involving biosensor performance enhancement by integrated surface-acoustic-wave (SAW) microstreaming is shown. The bioreactor consists of an encapsulated droplet with a biosensor on its periphery, with in situ streaming induced by SAW. This paper highlights the characterization by particle image tracking of the speed distribution inside the droplet. The analyte-biosensor interaction is then evaluated by finite element simulation with different streaming conditions. Calculation of the biosensing enhancement shows an optimum in the biosensor response. These results confirm that the evaluation of the Damköhler and Peclet numbers is of primary importance when designing biosensors enhanced by streaming. ©2010 American Institute of Physics
History: Received 17 November 2009; accepted 19 January 2010; published 8 February 2010
Permalink: http://link.aip.org/link/?BIOMGB/4/11102/1

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