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Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

Source: J. Biomed. Opt. 15, 016015 (2010); doi:10.1117/1.3299728

Published 4 February 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.63.L-
    Visual medical imaging
  • 87.50.wf
    Biophysical mechanisms of interaction (optical/infrared radiation)
  • YEAR: 2010
PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef SPIE
Nimit L. Patel, Zi-Jing Lin, and Yajuvendra Rathore
University of Texas at Arlington, Bioengineering Department, 501 West First Street, Arlington, Texas 76010

Edward H. Livingston
University of Texas Southwestern Medical Center at Dallas, Department of Surgery, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9156

Hanli Liu and George Alexandrakis
University of Texas at Arlington, Bioengineering Department, 501 West First Street, Arlington, Texas 76010
Surgeons often cannot see major vessels embedded in adipose tissue and inadvertently injure them. One such example occurs during surgical removal of the gallbladder, where injury of the nearby common bile duct leads to life-threatening complications. Near-infrared imaging of the intraoperative field may help surgeons localize such critical tissue-embedded vessels. We have investigated how continuous-wave (CW) imaging performs relative to time-gated wide-field imaging, presently a rather costly technology, under broad Gaussian beam-illumination conditions. We have studied the simplified case of an isolated cylinder having bile-duct optical properties, embedded at different depths within a 2-cm slab of adipose tissue. Monte Carlo simulations were preformed for both reflectance and transillumination geometries. The relative performance of CW versus time-gated imaging was compared in terms of spatial resolution and contrast-to-background ratio in the resulting simulated images. It was found that time-gated imaging offers superior spatial resolution and vessel-detection sensitivity in most cases, though CW transillumination measurements may also offer satisfactory performance for this tissue geometry at lower cost. Experiments were performed in reflectance geometry to validate simulation results, and potential challenges in the translation of this technology to the clinic are discussed. ©2010 Society of Photo-Optical Instrumentation Engineers
History: Received 15 June 2009; revised 18 November 2009; accepted 1 December 2009; published 4 February 2010
Permalink: http://dx.doi.org/10.1117/1.3299728

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