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Enhanced photothermal therapy assisted with gold nanorods using a radially polarized beam

Source: Appl. Phys. Lett. 96, 063702 (2010); doi:10.1063/1.3302461

Published 10 February 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.50.wp
    Therapeutic applications (optical/infrared radiation)
  • 42.62.Be
    Biological and medical applications of lasers
  • 87.17.-d
    Cell processes
  • YEAR: 2010
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PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef AIP
Hong Kang, Baohua Jia, Jingliang Li, Dru Morrish, and Min Gu
Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia
We report on the use of a radially polarized beam for photothermal therapy of cancer cells labeled with gold nanorods. Due to a three-dimensionally distributed electromagnetic field in the focal volume, the radially polarized beam is proven to be a highly efficient laser mode to excite gold nanorods randomly oriented in cancer cells. As a result, the energy fluence for effective cancer cell damage is reduced to one fifth of that required for a linearly polarized beam, which is only 9.3% of the medical safety level. ©2010 American Institute of Physics
History: Received 20 November 2009; accepted 6 January 2010; published 10 February 2010
Permalink: http://link.aip.org/link/?APPLAB/96/063702/1

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