Vir. J. Bio. Phys. Res. / Volume 20 / Issue 3 / CANCER PHYSICS

Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

Source: Chem. Commun. 46, 5509 (2010); doi:10.1039/c0cc00127a

Issue Date: 1 August 2010

ABSTRACT

^* Full Text: Access via Source Journal Abstract

PUBLICATION DATA

ISSN:

1553-9628 (online)

Publisher:

RSC

Sai Bi
Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. shushzhang@126.com

Jilei Zhang

Shusheng Zhang

Bysignificantly circumventing the typical problem of high background induced byexcess hemin itself, an ultrasensitive DNA amplified detection method isdeveloped based on nicking endonuclease (NEase) assisted strand scission cycle,which is further successfully applied in cancer cell detection. ©2010

Permalink:

http://dx.doi.org/10.1039/c0cc00127a

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Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

Source: Chem. Commun. 46, 5509 (2010); doi:10.1039/c0cc00127a