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Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes

Source: Appl. Phys. Lett. 97, 043701 (2010); doi:10.1063/1.3467194

Published 26 July 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.80.St
    Genomic techniques (biophysical research methods)
  • 87.15.Tt
    Electrophoresis (molecular biophysics)
  • 87.15.-v
    Biomolecules: structure and physical properties
  • 87.15.Pc
    Electronic and electrical properties of biomolecules
  • YEAR: 2010
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PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef AIP
Yuhui He,1 Lubing Shao,1 Ralph H. Scheicher,2 Anton Grigoriev,2 Rajeev Ahuja,2,3 Shibing Long,1 Zhuoyu Ji,1 Zhaoan Yu,1 and Ming Liu1
1Laboratory of Nano-Fabrication and Novel Devices Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, People's Republic of China
2Department of Physics and Astronomy, Condensed Matter Theory Group, Box 516, Uppsala University, SE-751 20 Uppsala, Sweden
3Department of Materials and Engineering, Applied Materials Physics, Royal Institute of Technology (KTH), SE-100 44 Stockholm, Sweden
We propose an approach for nanopore-based DNA sequencing using characteristic transverse differential conductance. Molecular dynamics and electron transport simulations show that the transverse differential conductance during the translocation of DNA through the nanopore is distinguishable enough for the detection of the base sequence and can withstand electrical noise caused by DNA structure fluctuation. Our findings demonstrate several advantages of the transverse conductance approach, which may lead to important applications in rapid genome sequencing. ©2010 American Institute of Physics
History: Received 31 March 2010; accepted 16 April 2010; published 26 July 2010
Permalink: http://link.aip.org/link/?APPLAB/97/043701/1

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