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Giant magnetoimpedance-based microchannel system for quick and parallel genotyping of human papilloma virus type 16/18

Source: Appl. Phys. Lett. 97, 043702 (2010); doi:10.1063/1.3467833

Published 26 July 2010

KEYWORDS and PACS
Keywords
PACS
  • 87.85.Ox
    Biomedical instrumentation and transducers
  • 85.75.-d
    Magnetoelectronics; spintronics
  • 85.70.Kh
    Magnetic thin film devices: magnetic heads (magnetoresistive, inductive, etc.); domain-motion devices, etc
  • 87.80.Ek
    Mechanical and micromechanical techniques (biophysical research methods)
  • 85.85.+j
    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
  • YEAR: 2010
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PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef AIP
Hao Yang,1 Lei Chen,1 Chong Lei,1 Ju Zhang,2 Ding Li,3 Zhi-Min Zhou,1 Chen-Chen Bao,1 Heng-Yao Hu,1 Xiang Chen,1 Feng Cui,1 Shuang-Xi Zhang,1 Yong Zhou,1 and Da-Xiang Cui1
1Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Dong Chuan Road 800, Shanghai 200240, People's Republic of China
2Institute of Gene Diagnosis, State Key Laboratory of Cancer Biology, Fourth Military Medical University, 17 Changle West Road, Xian, Shanxi 710032, People's Republic of China
3Center of Biological Diagnosis and Therapy, No. 261 Hospital of PLA, Beijing 100094, People's Republic of China
Quick and parallel genotyping of human papilloma virus (HPV) type 16/18 is carried out by a specially designed giant magnetoimpedance (GMI) based microchannel system. Micropatterned soft magnetic ribbon exhibiting large GMI ratio serves as the biosensor element. HPV genotyping can be determined by the changes in GMI ratio in corresponding detection region after hybridization. The result shows that this system has great potential in future clinical diagnostics and can be easily extended to other biomedical applications based on molecular recognition. ©2010 American Institute of Physics
History: Received 28 April 2010; accepted 1 July 2010; published 26 July 2010
Permalink: http://link.aip.org/link/?APPLAB/97/043702/1

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