Vir. J. Bio. Phys. Res. / Volume 20 / Issue 4 / INSTRUMENTATION DEVELOPMENT

An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

Source: Chem. Commun. 46, 5939 (2010); doi:10.1039/c0cc00748j

Issue Date: 15 August 2010

ABSTRACT

^* Full Text: Access via Source Journal Abstract

PUBLICATION DATA

ISSN:

1553-9628 (online)

Publisher:

RSC

Jinghua Chen
Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China. gnchen@fzu.edu.cn hhyang@fzu.edu.cn

Jing Zhang

Juan Li

Fengfu Fu

Huang-Hao Yang

Guonan Chen

Basedon the “nicking endonuclease assisted” detection strategy, a novel electrochemicalbiosensor for the sequence-specific detection of DNA with ultrahigh sensitivityand selectivity is developed. By employing the above strategy, thisDNA biosensor can detect as low as 0.068 fM targetDNA and exhibits high discrimination ability even against a single-basemismatch. ©2010

Permalink:

http://dx.doi.org/10.1039/c0cc00748j

Follow the below links to the current contents of these related journals:
Biointerphases | Biophysical Journal

Dynamic spectral-domain optical coherence elastography for tissue characterization

Dispersion of single-walled carbon nanotubes by DNA for preparing transparent conductive films

An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

Source: Chem. Commun. 46, 5939 (2010); doi:10.1039/c0cc00748j