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Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Source: Chem. Commun. 48, 1162 (2012); http://dx.doi.org/10.1039/c2cc16872c

Issue Date: 15 January 2012

PUBLICATION DATA
ISSN:
1553-9628 (online)
Publisher:
AIP is a member of CrossRef RSC
Dieter Verzele
Pfizer Analytical Research Centre, Department of Organic Chemistry, Ghent University, Krijgslaan 281-S4bis, B-9000 Ghent, Belgium. pat.sandra@ugent.be

Frédéric Lynen


Mike De Vrieze


Adrian G. Wright


Melissa Hanna-Brown


Pat Sandra

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool. ©2012
Digital Object Identifier: http://dx.doi.org/10.1039/c2cc16872c
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