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Nonlinear-optical brain anatomy by harmonic-generation and coherent Raman microscopy on a compact femtosecond laser platform

Source: Appl. Phys. Lett. 99, 231109 (2012); http://dx.doi.org/10.1063/1.3664345

Published 8 December 2011

KEYWORDS and PACS
Keywords
PACS
  • 87.63.lt
    Laser imaging in medicine
  • 42.62.Be
    Biological and medical applications of lasers
  • 42.65.Ky
    Optical frequency conversion; harmonic generation
  • 42.81.Wg
    Other fiber-optical devices
  • YEAR: 2011
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PUBLICATION DATA
ISSN:
1553-9601 (online)
Publisher:
AIP is a member of CrossRef AIP
Lyubov V. Doronina-Amitonova,1,2 Aleksandr A. Lanin,1 Olga I. Ivashkina,2,3 Marina A. Zots,2,3 Andrei B. Fedotov,1,2 Konstantin V. Anokhin,2,3 and Aleksei M. Zheltikov1,2,4
1Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Russia
2Department of Neuroscience, Kurchatov National Research Center, Moscow, Russia
3P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
4Department of Physics and Astronomy, Texas A&M University, College Station, Texas 77843, USA
An extended-cavity Cr:forsterite laser is integrated with a photonic-crystal fiber soliton frequency shifter and a periodically poled lithium niobate spectrum compressor for simultaneous harmonic-generation and coherent Raman brain imaging. Adapting the laser beam focusing geometry to the tissue morphology is shown to enable complementarity enhancement in tissue imaging by second- and third-harmonic generation, as well as coherent Raman scattering, facilitating quantitative image analysis. ©2011 American Institute of Physics
History: Received 30 August 2011; accepted 5 November 2011; published 8 December 2011
Digital Object Identifier: http://dx.doi.org/10.1063/1.3664345

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