Scitation Latest Published Articles

Design for manufacture of a micro-interdigitated electrode for impedance measurement in a biochemical assay

Tue, 14 Feb 2012 02:05:32 GMT

Linda Donoghue and Brian W. Anthony
The performance of interdigitated electrodes for impedance measurements in a microfluidic assay chamber is dependent upon the geometric design of the electrode pattern and can be significantly impacted by variability or defects in manufacturing or materials. For processes which rely on precise elect ... [Proc. SPIE 8251, 82510Y (2012)] published Mon Feb 13, 2012.

Design and analysis of a micromachined gyroscope

Tue, 14 Feb 2012 02:05:26 GMT

Nilgoon Zarei, Albert Leung, and John D. Jones
This paper describes the simulation and design of a MEMS thermal gyroscope and optimizing the design for increased sensitivity through the use of the Comsol Multiphysics software package. Two different designs are described, and the effects of working fluid properties are explored. A prototype of th ... [Proc. SPIE 8251, 82510X (2012)] published Mon Feb 13, 2012.

Nonspherical optofluidic lenses

Tue, 14 Feb 2012 02:05:20 GMT

Sergio Calixto, Martha Rosete-Aguilar, and Margarita Calixto-Solano
Usually optofluidic lenses are spherical (ball lenses), plano - concave or plano - convex. Here we present a method to fabricate non - ball small microfluidic lenses in the bulk of a polymer. The cavity of these lenses can be filled with a liquid by means of a syringe. Liquids present different refr ... [Proc. SPIE 8251, 82510V (2012)] published Mon Feb 13, 2012.

Multiple-stream flow and mixing of dissimilar polymeric solutions in abrupt microfluidic contraction/expansion geometries

Tue, 14 Feb 2012 02:05:16 GMT

Hiong Yap Gan and Yee Cheong Lam
In simple microfluidic contraction/expansion geometry, even a dilute polymeric solution is able to exhibit large upstream corner vortices and unstable entry flow patterns at high enough deformation rate (Deborah Number > 200). We have previously demonstrated a similar concept on multiple-stream flow ... [Proc. SPIE 8251, 82510U (2012)] published Mon Feb 13, 2012.

Multiplexed fluorescence detection for point-of-care

Tue, 14 Feb 2012 02:05:12 GMT

Li Shen, Mike Ratterman, Tyler Stites, David Klotzkin, and Ian Papautsky
We report on the development of a portable fluorescence detection system. By combining a CMOS sensor and crosspolarization scheme, we achieved multiplexed detection with a single white emission LED excitation. We demonstrated fluorescence detection of Fluorescein and Rhodamine B in PDMS channels and ... [Proc. SPIE 8251, 82510S (2012)] published Mon Feb 13, 2012.

Spiral inertial microfluidic devices for continuous blood cell separation

Tue, 14 Feb 2012 02:05:08 GMT

Nivedita Nivedita, Phillip Ligrani, and Ian Papautsky
Enrichment and separation of cell components of blood is critical to clinical diagnostics and therapeutics. Here we report on spiral inertial microfluidic devices which achieve continuous size-based separation of cell mixtures with high throughput. These devices rely on hydrodynamic forces acting on ... [Proc. SPIE 8251, 82510R (2012)] published Mon Feb 13, 2012.

3D nanoporous optofluidic device for high sensitivity SERS detection

Tue, 14 Feb 2012 02:05:03 GMT

Soroush H. Yazdi and Ian M. White
We report the demonstration of an optofluidic surface enhanced Raman spectroscopy (SERS) device that leverages nanoporous microfluidics to dramatically increase the SERS performance. A number of optofluidic approaches have been used to improve the detection limit of SERS in microfluidic channels, in ... [Proc. SPIE 8251, 82510Q (2012)] published Mon Feb 13, 2012.

Optofluidic backplane as a platform for modular system design

Tue, 14 Feb 2012 02:04:58 GMT

M. Brammer, C. Megnin, M. Siegfarth, S. Sobich, A. Hofmann et al.
Most Lab-on-a-Chip systems require a platform with external supply and control units to be operated. In this manuscript, we report on the development of a modular optoelectronic microfluidic backplane, enabling the flexible interconnection, supply, and control of microfluidic and optofluidic devices ... [Proc. SPIE 8251, 82510O (2012)] published Mon Feb 13, 2012.

Highly accurate measurement of varying drug dosage for real-time analysis of chemo-mechanical response of cardiomyocytes

Tue, 14 Feb 2012 02:04:55 GMT

Avneet Bajwa, Behraad Bahreyni, and Ash M. Parameswaran
A recent advancement in the study of drug development for cardiovascular diseases is based on measuring the mechanical response of a single cardiomyocyte to various drug concentrations. This method requires delivering a specific dose of the drug over a short period of time while measuring the forces ... [Proc. SPIE 8251, 82510N (2012)] published Mon Feb 13, 2012.

Optical sensing for on-chip digital microfluidics

Tue, 14 Feb 2012 02:04:52 GMT

Jacqueline A. Nichols, Emily L. Landry, Brandon Born, Michael Wiltshire, Christopher M. Collier et al.
A digital microfluidic architecture is introduced for micron-scale localized fluid actuation and in in-situ optical sensing. Contemporary device integration challenges related to localization and device scalability are overcome through the introduction of a bi-layered digital microfluidic multiplexe ... [Proc. SPIE 8251, 82510L (2012)] published Mon Feb 13, 2012.

Lab-on-a-chip sensor for measuring Zn by stripping voltammetry

Tue, 14 Feb 2012 02:04:49 GMT

Xing Pei, Wenjing Kang, Wei Yue, Adam Bange, Hector R. Wong et al.
This work reports on continuing development of a lab-on-a-chip sensor for electrochemical detection of heavy metal zinc in blood serum. The sensor consists of a three electrode system, including an environmentally-friendly bismuth working electrode, a Ag/AgCl reference electrode, and a gold auxiliar ... [Proc. SPIE 8251, 82510K (2012)] published Mon Feb 13, 2012.

A simple single-detector system for simultaneous monitoring of O and CO gas concentration

Tue, 14 Feb 2012 02:04:46 GMT

Rahul Dixit, Li Shen, Mike Ratterman, Ian Papautsky, and David J. Klotzkin
In this paper, we present a system for fluorescent monitoring of multiple gas concentrations using a simple and robust single detector setup. Two gas-sensitive fluorescent films are illuminated by two separate excitation sources modulated at different frequencies. Cross-polarization is used to shiel ... [Proc. SPIE 8251, 82510J (2012)] published Mon Feb 13, 2012.

Variation analysis of flow rate delivered using a blister pump

Tue, 14 Feb 2012 02:04:42 GMT

Sivesh Selvakumar, Rodrigo Linares, Aaron Oppenheimer, and Brian Anthony
Components for on-chip storage and delivery of liquid reagent are necessary for many commercial applications of lab-on- a-chip technology. One such system uses a 'blister-pack' that is pushed by an actuator. This paper explores the sensitivity of the flow rate produced by a blister-actuator pair to ... [Proc. SPIE 8251, 82510I (2012)] published Mon Feb 13, 2012.

Polymer micromolds with near optical quality surface finishes

Tue, 14 Feb 2012 02:04:39 GMT

Pun-Pang Shiu, George K. Knopf, and Suwas Nikumb
Disposable microfluidic systems are used to avoid sample contamination in a variety of medical and environmental monitoring applications. A contactless hot intrusion (HI) process for fabricating reusable polymer micromolds with near "optical quality" surface finishes is described in this paper. A me ... [Proc. SPIE 8251, 82510H (2012)] published Mon Feb 13, 2012.

Dimensional variation of polymer substrate electrode production

Tue, 14 Feb 2012 02:04:35 GMT

Brian W. Anthony and Kasra Namvari
Electrodes are necessary components for measuring changes in electrical properties in many microfluidic devices. The consistency of the dimensions of manufactured electrode is critical to the repeatability of measurements. We analyze the electrode dimensions to characterize a manufacturing process. ... [Proc. SPIE 8251, 82510G (2012)] published Mon Feb 13, 2012.

Modeling distributed feedback GaAs-based lasers in dentistry

Tue, 14 Feb 2012 02:01:28 GMT

Meng-Mu Shih
Distributed-feedback gallium-arsenide-based lasers with metal-gratings can generate stable wavelength at 980nm for applications in dentistry. This model uses the periodic optical waveguide method to calculate the coupling coefficient, which is a key parameter of laser performance. This model shows h ... [Proc. SPIE 8208, 82080C (2012)] published Mon Feb 13, 2012.

Computer-aided 3D-shape construction of hearts from CT images for rapid prototyping

Tue, 14 Feb 2012 02:00:59 GMT

Masayuki Fukuzawa, Yutaro Kato, Nobuyuki Nakamori, Seiichiro Ozawa, and Isao Shiraishi
By developing a computer-aided modeling system, the 3D shapes of infant's heart have been constructed interactively from quality-limited CT images for rapid prototyping of biomodels. The 3D model was obtained by following interactive steps: (1) rough region cropping, (2) outline extraction in each s ... [Proc. SPIE 8290, 829017 (2012)] published Mon Feb 13, 2012.

Two-component injection molding for micofluidic devices

Tue, 14 Feb 2012 01:55:50 GMT

Holger Becker and Claudia Gartner
In recent years there has been an increasing demand for functional integration in microfluidic devices. This integration often requires the use of different materials in order to generate the demanded performance. Typical examples for such integrated functionalities are on-chip valves or areas used ... [Proc. SPIE 8251, 82510E (2012)] published Mon Feb 13, 2012.

A lab-on-a-chip system for the development of complex assays using modular microfluidic components

Tue, 14 Feb 2012 01:55:44 GMT

Nadine Hlawatsch, Richard Klemm, Cornelia Carstens, Thomas Brandstetter, Holger Becker et al.
For complex biological or diagnostic assays, the development of an integrated microfluidic device can be difficult and error-prone. For this reason, a modular approach, using individual microfluidic functional modules for the different process steps, can be advantageous. However often the interconne ... [Proc. SPIE 8251, 82510D (2012)] published Mon Feb 13, 2012.

Point-of-care, portable microfluidic blood analyzer system

Tue, 14 Feb 2012 01:55:41 GMT

Teimour Maleki, Todd Fricke, JT Quesenberry, Paul Todd, and James F. Leary
Recent advances in MEMS technology have provided an opportunity to develop microfluidic devices with enormous potential for portable, point-of-care, low-cost medical diagnostic tools. Hand-held flow cytometers will soon be used in disease diagnosis and monitoring. Despite much interest in miniaturiz ... [Proc. SPIE 8251, 82510C (2012)] published Mon Feb 13, 2012.

Integrated flexible optitrode for neural stimulation and recording

Tue, 14 Feb 2012 01:55:37 GMT

Szu-Te Lin, John A. Dani, John C. Wolfe, and Wei-Chuan Shih
We present an integrated flexible probe for deep brain optical stimulation and electrical recording, termed as "Optitrode". This device features an annular light guide consisting of layered transparent polymer and silica, and is fabricated by a unique process we developed: V-groove guided capillary ... [Proc. SPIE 8251, 82510B (2012)] published Mon Feb 13, 2012.

Miniaturized neural interfaces and implants

Tue, 14 Feb 2012 01:55:33 GMT

Thomas Stieglitz, Tim Boretius, Juan Ordonez, Christina Hassler, Christian Henle et al.
Neural prostheses are technical systems that interface nerves to treat the symptoms of neurological diseases and to restore sensory of motor functions of the body. Success stories have been written with the cochlear implant to restore hearing, with spinal cord stimulators to treat chronic pain as we ... [Proc. SPIE 8251, 82510A (2012)] published Mon Feb 13, 2012.

A microfluidic device for studies of the orientational dynamics of microrods

Tue, 14 Feb 2012 01:55:30 GMT

Y. N. Mishra, J. Einarsson, O. A. John, P. Andersson, B. Mehlig et al.
We describe a microfluidic device for studying the orientational dynamics of microrods. The device enables us to experimentally investigate the tumbling of microrods immersed in the shear flow in a microfluidic channel with a depth of 400 [mu]m and a width of 2.5 mm. The orientational dynamics was r ... [Proc. SPIE 8251, 825109 (2012)] published Mon Feb 13, 2012.

Magnetic particle-based sample-prep and valveing in microfluidic devices

Tue, 14 Feb 2012 01:55:27 GMT

Richard Klemm, Nadine Hlawatsch, Thomas E. Hansen-Hagge, Holger Becker, and Claudia Gartner
There is a need to design an integrated microfluidic platform as simple and lean as possible in order to meet the requirements for a miniaturized system. Magnetic particles show a great versatility in performing several of the functions necessary in many microfluidic assays. We therefore have develo ... [Proc. SPIE 8251, 825108 (2012)] published Mon Feb 13, 2012.

Fast self-assembly kinetics of alkanethiols on gold nanoparticles: simulation and characterization by localized surface plasmon resonance spectroscopy

Tue, 14 Feb 2012 01:55:24 GMT

Sasan Asiaei, Ryan C. Denomme, Chelsea Marr, Patricia M. Nieva, and Mathilakath M. Vijayan
This study demonstrates improved kinetics for the formation of self-assembled monolayers (SAMs) of alkanethiols on gold nanoparticle substrates. A computational model was developed to predict SAM growth kinetics. Based on the predictions from the model, SAMs of 11-mercaptoundecanoic acid (11-MUA) an ... [Proc. SPIE 8251, 825107 (2012)] published Mon Feb 13, 2012.