This study reports on the successful use of magnetic albumin nanosphere (MAN) with in vivo magnetohyperthermia (MHT) in a mouse Ehrlich tumor. Maghemite nanoparticles (8.9 nm average diameter) were encapsulated within MAN (73.0 nm average diameter). Ehrlich tumor obtained after implantation of tumor cells in the subcutaneous tissue of mice was used as a model throughout this study. MHT was performed with MAN (40 μL) containing 1.2 × 1015 particle/mL and 40 Oe amplitude ac magnetic field oscillating at 1 MHz. Animals not treated, treated with MAN, or exposed to the ac field were used as controls. Histopathological analysis was carried out after 2, 5, or 11 days of tumor implantation. We found that the MHT most efficient condition was obtained while applying the ac field protocol twice a day during three consecutive days. Further, in this ac field-treated group no proliferation cells were detected.
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1 April 2011
PROCEEDINGS OF THE 55TH ANNUAL CONFERENCE ON MAGNETISM AND MAGNETIC MATERIALS
14-18 November 2010
Atlanta, Georgia
Research Article|
Magnetism and Magnetic Materials|
March 28 2011
Investigation of a magnetohyperthermia system efficacy
F. A. Portilho;
F. A. Portilho
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
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L. L. C. Estevanato;
L. L. C. Estevanato
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
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A. L. Miranda-Vilela;
A. L. Miranda-Vilela
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
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M. F. M. Almeida-Santos;
M. F. M. Almeida-Santos
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
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C. E. de Oliveira-Cavalcanti;
C. E. de Oliveira-Cavalcanti
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
2
Universidade Federal de Alagoas, Faculdade de Medicina-FAMED
, Maceió AL, 57072-970, Brazil
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B. M. Lacava;
B. M. Lacava
3
Universidade de Brasilia, Instituto de Química
, Brasília DF 70910-900, Brazil
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A. R. Simioni;
A. R. Simioni
4
Universidade de São Paulo, Departamento de Química, Laboratório de Fotobiologia e Fotomedicina
, FFCLRP, 14040-901, Ribeirão Preto-SP, Brazil
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A. C. Tedesco;
A. C. Tedesco
4
Universidade de São Paulo, Departamento de Química, Laboratório de Fotobiologia e Fotomedicina
, FFCLRP, 14040-901, Ribeirão Preto-SP, Brazil
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P. C. Morais;
P. C. Morais
5
Universidade de Brasilia, Instituto de Física
, Brasília DF 70910-900, Brazil
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Z. G. M. Lacava
Z. G. M. Lacava
a)
1
Universidade de Brasilia, Instituto de Ciências Biológicas
, Brasília DF 70910-900, Brazil
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a)
Electronic mail: zulmira@unb.br.
J. Appl. Phys. 109, 07B307 (2011)
Article history
Received:
October 05 2010
Accepted:
November 30 2010
Citation
F. A. Portilho, L. L. C. Estevanato, A. L. Miranda-Vilela, M. F. M. Almeida-Santos, C. E. de Oliveira-Cavalcanti, B. M. Lacava, A. R. Simioni, A. C. Tedesco, P. C. Morais, Z. G. M. Lacava; Investigation of a magnetohyperthermia system efficacy. J. Appl. Phys. 1 April 2011; 109 (7): 07B307. https://doi.org/10.1063/1.3559498
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